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In order for B12 to be absorbed from the gut, it requires a specific protein called intrinsic factor (IF)

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This surplus of electron donors in the mitochondrial electron transport chain can overwhelm and impair mitochondrial complex I (Yan et al., 2016)

(2) NNMT catalyzes the N-methylation of nicotinamide using SAM as a methyl donor, consuming both substrates in the process

Even before ephedra was banned by the FDA, the Olympics, NFL, and US Military banned the use of ephedra