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Sci Rep 15 , 38873 (2025)

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Instead, therapeutic modulation of GSH must be tailored to disease context, reflecting the fundamental GSH paradox: whereas cancer therapy often seeks to deplete elevated GSH to induce oxidative stress and cell death, neurodegenerative and inflammatory diseases may require restoration of GSH homeostasis

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High concentrations of OxLDL activates caspase 3 in a Fas-independent manner, thus causing apoptosis with characteristic DNA fragmentation [168]

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2018;6:243.ArticlePubMedPMC 15

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