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This dose falls within the effective clinical range while allowing room to increase if response is minimal

It engages binding sites with approximately ten times greater affinity than that of comparable NNMT inhibitors [2]

This inhibition reduces intracellular 1-methylnicotinamide (1-MNA) production (EC50 = 2.3 M) and preserves nicotinamide availability for the NAD+ salvage pathway

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This mechanistic distinction means the compound could theoretically be combined with appetite-suppressing peptides for a protocol that simultaneously reduces energy intake (GLP-1) and restores adipocyte energy expenditure (NNMT inhibition) though this remains purely theoretical without published combination data