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Description

Esculetin , administered at 5 mg/kg in a rat model of TNBS-induced IBD, demonstrated potent intestinal anti-inflammatory effects, preventing an increase in MDA levels, countering GSH depletion, reducing epithelial cell apoptosis, and inhibiting the secretion of pro-inflammatory cytokines (IL-1, IL-2, IFN-) in vitro

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Comment: Some commenters expressed concerns with the proposal to require that transfer of care modifiers be reported for both formal (per our current policy) and other transfers of care