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To view a copy of this license, visit About this article Cite this article Alkilany, A.M., Alsotari, S., Alkawareek, M.Y

Copper amine oxidase 1 (CuAO1) is another candidate enzyme involved in NO synthesis (Wimalasekera et al., 2011)

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549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons