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Current treatments such as dimethyl fumarate (DMF) are already approved to treat MS through stabilizing the transcription factor Nrf2 which then induces the expression of antioxidant response element genes such as GSH (Bresciani et al., 2023)

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Furthermore, elucidating the interplay between GSH and critical molecular pathways, including mitochondrial function and lipid metabolism, could provide valuable mechanistic insights and help identify more biomarkers predictive of treatment response

Owing to negative perceptions surrounding oral glutathione intake, many researchers have focused on NAC supplementation or intravenous injections as alternatives to oral glutathione administration