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Adv Nutr 8:126136 Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, Cooperman S, Eckhaus M, Rouault T, Mishra L, Deng CX (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

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Mechanistically, mitochondrial dysfunction, as discussed above, is an increasingly recognized contributor, particularly in diabetic nephropathy, in which mitochondrial ROS production exceeds the local antioxidant capacity [13,34]

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Cancer Lett (2014) 345:1408

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More recently, studies of transgenic mouse models have revealed that the triplication of CBS gene also contributes to cognitive phenotypes and that CBS and DYRK1A show epistatic interactions ( CBS encodes a pyridoxal 5-phosphate-dependent enzyme that catalyzes the first reaction in the transsulfuration pathway

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Nat Rev Nephrol (2018) 14:2647

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