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The researchers followed 17 patients over a one-year period, tracking their pain levels and improvement after treatment

Nerve roots, the parts of nerves that leave the spinal cord, exit above each vertebra through openings called intervertebral canals

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The most affected phenotype identified was that of Igfbp4 ko mice who were growth retarded at birth and displayed poor postnatal growth (30)

It appears to enhance the fundamental cellular processes of tissue repair, resulting in structurally improved healing rather than just symptomatic relief