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[57] reported that 2-deoxyglucose (2-DG), a glycolytic inhibitor and a caloric restriction mimetic, suppressed the LPS-induced nuclear accumulation of PKM2 and the phosphorylation of STAT3

Additionally, certain cellular events including autophagy, endoplasmic reticulum stress, inflammatory infiltration and microcirculatory dysfunction, have been found involvement with the pathogenesis of APAP-caused liver injury ( via mediating endoplasmic reticulum (ER) stress ( via mitochondrial avenue (Figure 4)