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MathewRKarpCMBeaudoinBVuongNChenGChenHYet al

For instance, NRF2 inhibitors, such as Brusatol and Brucein D, promote ubiquitination and proteasomal degradation of NRF2, enhancing chemosensitivity in cancers like AML, endometrial cancer, and pancreatic ductal adenocarcinoma

Another significant group includes carotenoids such as beta-carotene, lutein, and zeaxanthin, which are found in colorful fruits and vegetables like carrots and spinach [203]

10.1146/annurev.pharmtox.44.101802.121851 77 KlimaczewskiC

A key cellular antioxidant, glutathione (GSH), is intimately involved in these processes by maintaining redox homeostasis and modulating signaling pathway activities [47]