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Neurological disorders In conditions like Parkinsons and Alzheimers diseases, disruptions in cellular Ca 2+ regulating systems in the plasma membrane, ER, and mitochondria can manifest in synaptic dysfunction, decreased plasticity, and neuronal degeneration [286,287,288]

This semi-LASER approach has recently been shown to have similar accuracy to MEGA-sLASER (an edited MRS sequence) for quantification of GABA in human brain at 7T 92 and we expect similar performance for Glu and Gln

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doi: 10.1016/j.biopsych.2014.12.023 108 YanoJMYuKDonaldsonGPShastriGGAnnPMaLet al