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23,25 Additionally, cytoplasmic p53 inhibits autophagy via mTOR activation under basal conditions, whereas nuclear p53 promotes autophagy through mTOR-independent mechanisms under stress

Clinicians have always taught patients to use the upper outer quadrant of the buttocks to avoid injury to the sciatic nerve that could be reached if a regular sized needle was used in the lower portion of the buttocks

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However, the role for metabolite acquisition in pathogenesis remains unclear