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These neurons, which possess highly specialized morphological features and high bioenergetic demands, are particularly susceptible to mitochondrial dysfunction

Moreover, clinicopathological studies have demonstrated reduced proliferation in EMT-transformed circulating tumor cells (CTCs) and disseminated tumor cells during and after chemotherapy treatment [36]

By highlighting the insights from recent studies and identifying knowledge gaps regarding metformin-microbiota interplay, we aim to highlight the path toward more personalized and effective diabetes management strategies and moving beyond the one-size-fits-all approach

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(C) Genomic screening for induced mutations at the site of interest targeted by the sgRNA