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Using the BioGRID database 26 as a reference, we find that interactions of 158 of these targets with human pathogenic viruses have been reported before, which represents a highly significant enrichment among reported interactions between enzymes and viruses (Fishers exact test p = 9.1 10 12 , odds ratio 1.93.4) and supports their central role in viral replication across diverse viruses

However, in non-APL tumors, ATO faces a metabolic bottleneck that limits its efficacy, because a crucial aspect of ATOs pharmacological effects is that the parent compound is not the ultimate cytotoxic effector

10.1159/000493232 82 LiuZ.LiY.ZhuY.LiN.LiW.ShangC.et al (2022)

Autism 7, 49

IRF2 and POU2F1 signaling was also significantly downregulated in CTNNB1-mutated HCC TCGA patients