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Calabrese, G

The debate on whether energy metabolism overload or deprivation plays a more crucial role in the occurrence and progression of cardiovascular diseases continues

FIGURE 4 5.1 Intestinal mechanical barrier The intestinal mechanical barrier is primarily comprised of intestinal epithelial cells (IEC), intercellular junctions, basement membrane, and the submucosal lamina propria, which collectively form the structural foundation of the intestinal mucosal barrier

In the first phase, the increase in glucose transport rate, independent from insulin presence, is mediated by the translocation, induced by the contraction, of glucose transporters, called GLUT4, on the cytoplasmatic membrane of the muscle cell

However, these models fail to accurately replicate physiological conditions due to their simplified (2D) microenvironment, phenotypic and genetic instability and functional alterations in culture [48]