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*Correspondence: Xi Cheng, [email protected] Niu, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Dementia and Neurodegenerative Diseases, a section of the journal Frontiers in Neurology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Although the Food and Drug Administration (FDA) established the mandatory fortification of all enriched cereal grain products with folic acid in 1996, full implementation, providing 140 g per 100 g of product, was achieved in 1998 (65)