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Translational Gaps of Experimental Studies Clearly, early research has indicated that different animal species, including guinea pigs, hamsters, and rats, were used to study the pathogenesis of DILI (reviewed evidence [52])

We found that loss of MPC1 diminished the NADPH/NADP+ ratio and elevated the GSSG/GSH ratio in these cells (Figure 8A, B)

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Curr Opin Pharmacol 7:398403 Giordano G, White CC, McConnachie LA, Fernandez C, Kavanagh TJ, Costa LG (2006) Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione deficiency

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