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Nat Rev Mol Cell Biol 20:590607

Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway

Subcutaneous is the most common route for general systemic delivery

Further support for a direct contribution of glutamate in the disease process came from blocking studies, applying Memantine, an N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor antagonist