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Notably, this study identified coordinated upregulation of TGR5 in subcutaneous adipose and jejunal tissues with core lipogenic genes ( PPAR , SREBP-1c ) in the RPG group, suggesting a novel signaling cascade: RPG activates jejunal TGR5 signaling, inducing secretion of INS, GLP-1, and 5-HT, which amplify the activation of master regulators ( PPAR , SREBP-1c ), ultimately driving systemic lipogenic gene networks [66, 67]