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Furthermore, OS is associated with increased plasma activity of prolidase, a key enzyme in collagen turnover and matrix remodeling, promoting the development of BPH (213)

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10.1186/s12951-025-03172-w 69 JieK

Although the probiotic supplement modulated the composition of gut microbiota, it was not effective at restoring control-like composition and it had no influence on the progression of the disease as measured by the ALS Functional Rating ScaleRevised (ALSFRS-R)