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DEM is an electrophilic reagent that forms a conjugate with GSH, leading to rapid GSH depletion and increased cystine import [52,53,54,55]

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Chronic treatment with EGCG (50 and 100 mg/kg, oral gavage 30 min before lipopolysaccharide/ Brucella abortus administration) for 21 days restored the period of immobility, post swim fatigue, thermal hyperalgesia, oxidativenitrosative stress (increased lipid peroxidation, nitrite levels and decreased endogenous antioxidant enzymes such as SOD, GSH and catalase), and inflammatory mediators (increased TNF- and tissue growth factor- (TGF-) levels) in a mouse model of immunologically induced chronic fatigue (Sachdeva et al

Zimmer, E

Control over polymer architecture and degradability is critically dependent on the underlying polymerization mechanism