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H NMR (200 MHz, CDCl 3 ) d 4.77 (ddd, J = 13.6, 9.1, 4.6 Hz, CHONO 2 , 1H), 3.61 (ddd, J = 13.6, 9.1, 4.6 Hz, CHOH, 1H), 2.89-2.84 (m, OH, 1H), 2.20-2.10 (m, CH 2 , 2H), 1.80-1.50 (m, CH 2 , 2H), 1.49-1.20 (m, CH 2 , 4H)

Despite decades of intensive research, the exact mechanisms driving the onset and progression of AD remain incompletely understood, underscoring the urgent need for continued investigation into its pathophysiology and the development of effective therapeutic interventions (Korczyn and Grinberg, 2024)

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Diabetes 54:21322142 Reinbothe TM, Ivarsson R, Li DQ et al (2009) Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion