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therefore, deficient RBCs exhibit impaired antioxidant capacity and increased susceptibility to oxidative stress

While both provide essential nutrients, folic acid is generally better absorbed and utilized by the body than its natural counterpart, folate (2)

Remember that dietary supplements are designed to complement a healthy lifestylenot replace a balanced diet or appropriate medical care

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Therefore, it is likely that FA-induced oxidative cytotoxicity might be more prevalent in blood-derived cells, which is consistent with the hematopoietic phenotypes reported in IBMFS/AMeD patients