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Drugs such as amsacrine, etoposide, and doxorubicin target topoisomerase type II (type II), while cytotoxic alkaloids and camptothecin (CPT) are recognized as inhibitors of type I [74]

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These DNA-damage recognition proteins have been shown to deliver signals from DNA breaks to downstream proteins such as p53, p73 and mitogen-activated protein kinases (MAPK), which activate apoptosis and other forms of cell death [21]

Although astrocytes can utilize fatty acids as an alternative energy source, prolonged reliance on lipid oxidation results in oxidative stress and mitochondrial impairment, exacerbating neurodegeneration 82

ISBN: 9780815344643