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Thromb Haemost (2016) 115(3):5919

This keeps vitamin B12 levels up between shots, helping health and preventing symptoms

Mechanistically, mTORC1 promotes the proteasome-mediated destabilization of CREB2 to suppress SIRT4 (a mitochondria-localized member of the sirtuin family), which inhibits GDH, thereby enhancing GDH enzymatic activity