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(2012), 9cRA was repeatedly administered through the intra-nasal route as intracerebral delivery is not feasible for repeated drug administration and may require chronic cannulation, whereas small molecules bypass the bloodbrain barrier and reach brain parenchyma non-invasively if delivered via the intranasal route

This means that the synapse mitochondria have additional functions at the nerve terminals, which may include Ca 2+ buffering directly affecting the firing probability of neurons [37, 38]

Cependant, la capacit de synthse de la L-carnitine chez les nourrissons est faible, reprsentant seulement 12 15 % de celle d'un adulte, en particulier chez les prmaturs, ce qui ne peut satisfaire leurs besoins mtaboliques normaux

Invitrogen, D1306)

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