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Of these, SREBP-1c is predominantly expressed in the liver, where it governs TG synthesis, whereas SREBP-2 is ubiquitously distributed and regulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol biosynthesis (Li et al

doi: 10.1161/CIRCRESAHA.118.312708 23 Fernandez-CaggianoMKamyninaAFrancoisAAPrysyazhnaOEykynTRKrasemannSet al

Of note, it is often advisable to submit a pre-submission Q-submission (pre-subs) to the FDA before submitting a premarket submission in order to align on expectations, such as clinical evidence and other testing expectations

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