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The protein: inhibitor complex was mixed in a 1:1 ratio (1 L protein: inhibitor complex and 1 L reservoir solution containing 100 mM sodium acetate pH 8.09.0, 200 mM Tris-HCl pH 8.09.0, 2535 % (w/v) PEG4000)

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In contrast, erastin failed to induce ferroptosis in our in vitro model, potentially because, as previously published, CLL cells are inherently limited in their ability to take up cystine under baseline conditions (Supplementary Fig

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Sphingosine-1-phosphate (S1P), by inhibiting MMPs and promoting glycocalyx synthesis, has shown protective effects in preclinical models