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Nat Chem Biol 18:470481

In contrast, Type 4 HH is attributed to a mutation in the ferroportin (FPN) gene, which encodes the duodenal iron-regulated transporter (Schimanski et al., 2005[375])

Re-evaluation of the hCMEC/D3 based in vitro BBB model for ABC transporter studies

The mechanism is related to metabolic regulation and increased chemosensitivity of cancer cells: by inhibiting NNMT, the product disrupts the energy supply of cancer cells, making them more vulnerable to chemotherapy, while protecting the metabolic balance of normal cells and reducing side effects