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During development and progression of atherosclerosis, Nrf2 signaling modulates many physiological and pathophysiological processes, like regulation of lipid homeostasis, CD36 gene expression regulation, foam cell formation, macrophage polarization, immunity regulation (Th2 differentiation and inhibition of pro-inflammatory gene expression through NFB down-regulation), redox regulation and inflammation, improvement of endothelial dysfunction, as well as GSH synthesis and utilization (234245)

Neurological sciences: official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Front Nutr 2023;10:1085248

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Clinically, cagrilintide is being studied for weight management, but research-use cagrilintide is not an approved weight-loss drug