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68% had decompensated cirrhosis, 20% had HCC, 8% FHF

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Statements Author contributions YuH and YR drafted this manuscript, YM, DC, TZ, SF, WL, YiH, HL helped to revise the manuscript, J-FX, JP and BZ helped to revise the manuscript and were responsible for leading this work

Introduction -thalassemia is the most common inherited disease, characterized by decreased or absent -globin chain synthesis and hemoglobin A production ( The incidence of myocardial iron overload in transfusion-dependent -thalassemia patients has increased from 11.4%15.1% in early studies to 26.1%36.7% in recent studies ( As iron loading progresses, the capacity of transferrin to bind and detoxify iron is eventually exceeded, leading to non-transferrin-bound iron in plasma, which promotes oxidative stress, mitochondrial dysfunction, and ferroptosis ( Mechanisms of myocardial injury caused by iron overload Studies have shown that iron myocardial overload causes myocardial dysfunction

10.1093/nar/gky641 47 KaupmannK.Simon-ChazottesD.GunetJ.-L.JokuschH