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Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment

Journal of Clinical Investigation, 63, 53-58

16 These biologics have proven efficacy, safety, and tolerability for the prevention and treatment of both episodic and chronic migraine in phase II and phase III randomized, placebo-controlled clinical trials