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[DOI] [PMC free article] [PubMed] [Google Scholar] Al-Sajee D., Oliveria J.P., Sehmi R., Gauvreau G.M

1 Introduction Rheumatoid arthritis (RA) is a multifactorial chronic autoimmune disease of unknown aetiology, which typically involves the joints and mostly manifests as symmetric polyarthritis in the large and small joints ( As a fundamental organelle, mitochondria are known as the energy centre of cells, which execute and coordinate various metabolic processes within cells and meet the energy demands of cells through the oxidative phosphorylation (OXPHOS) system

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[26] Other research focused on carnitine and muscle weakness seems to support carnitines effects relating to muscle integrity

Thus, ALKBH5 supports stem cell self-renewal and multilineage potential by preventing excessive m6A methylation that would otherwise mark transcripts for degradation or altered splicing