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Since then, numerous investigations have revealed the effects of GIP on multiple organs [14]

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Gelo et al

In TCM, Gegen ( Pueraria lobata (Willd.) Ohwi) is used to treat diarrhea due to spleen deficiency, while puerarin, the main active ingredient of Gegen, can regulate the expression of CRF1, p-ERK/ERK, and sealin, enhance the proliferation of colonic epithelial cells, repair the colonic mucus barrier, and improve the abdominal pain and diarrhea caused by IBS-D (Wang et al., 2021)