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ER is typically associated with secondary sex characteristics and regulation of the menstrual cycle in females and sperm maturation in males [86]

doi:10.1016/j.bjorl.2014.09.008 Yu S, Liu F, Cheng Z, Wang Q

Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1 (VCIP135) binds and stabilizes MAT2A in response to folate signaling in HCC and promotes tumor formation and progression in DEN/high-fat diet (HFD)induced HCC mouse models (Fig

PMID 11134893

It was reported that BMAL1 deficient mice had altered circadian rhythm of circulating IGF-1 levels (Patel et al., 2016), and CRY1 and 2 deficient mice had reduced IGF-1 production ( Due to the difficulty in measuring pulsatile GH secretion, the interaction between the GH-IGF-1 axis and circadian clock warrants further detailed research