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The FDA approved naloxone in 1971 as a prescription-only medication for intravenous, intramuscular, and subcutaneous administration to reverse postoperative respiratory depression induced by opioid analgesics

Acknowledgments The authors would like to dedicate this article to the defenders of Ukraine, the warriors whose health directly depends on the integrity of their intestinal wall

and UDP-N-acetylglucosamineN-acetylmuramyl pentapetide (MurG)(Dde_1042,PM_CB = 0.68, PM_CuB = 0.67) had a differential methylation pattern (Supplementary File S12)

NMR experiments were recorded on Agilent DD2 400 MHz spectrometers at ambient temperature

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