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The most severe potential adverse effect is seizure

During this step, known as the propagation phase,10 TF becomes less important, because the reaction is mainly driven by the FVIIa/FXa and FVa/FXa complexes.18,24 To further understand to what extent tumor cell TF contributes to thrombin generation, two different strategies were used: (i) inhibiting cell-associated TF with a specific anti-TF antibody, and (ii) performing the assay in FVII-deficient plasma

It has been demonstrated that the activation of the mTORC1 pathway is associated with cancer cells' dependence on glutamine [97]

Heberle, C