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Vadlapudi AD, et al

A literature search was conducted from January 2000 to December 2022 using multiple databases including Web of Science, Wiley, Springer, PubMed, Elsevier Science Direct, Google Scholar, the Core Collection, Scopus, and the Cochrane Library to collect and evaluate peer-reviewed literature regarding the neuroprotective role of metformin against DM-induced neurodegenerative events

Antioxidants from food may indirectly affect weight loss because protection from oxidative stress might reduce chronic inflammation and metabolic dysfunction, two potential factors in the development of obesity

FIGURE 1 At histopathological level, the main AD hallmarks are: (i) extracellular -amyloid (A) deposits, and (ii) intracellular neurofibrillary tangles (NFTs), containing bundles of paired helical filaments of the microtubule-associated hyperphosphorylated protein tau (Grundke-Iqbal et al., 1986

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