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doi: 10.7326/0003-4819-137-12-200212170-00007

Acta Endocrinol

2018, doi: 10.1038/EJCN.2017.132

For instance, Bifidobacterium bifidum , a potent immunomodulator in human diseases, induces the production of regulatory T cells (Verma et al., 2018), regulates helper T cell 2 and Th17-mediated immune responses in the intestine, inhibits the production of pro-inflammatory cytokines such as TNF-, IL-6, IL-1, IL-18, IL-22, and IL-9, while promots the expression of anti-inflammatory cytokines such as IL-10, IL-4, and IL-5 ( Faecalibacterium prausnitzii, Clostridium, Eubacterium rectale , and Roseburia demonstrate pronounced enrichment under these conditions

Therefore, the choice of suitable flour packaging, which is not permeable to both oxygen and moisture, is of critical importance in limiting losses of added folic acid, and it must be taken into account when planning a fortification program in countries with a tropical environment