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Among cases of severe hepatotoxicity occurring during VPA therapy, survival has been reported mainly in those patients treated with carnitine [6467], and this approach is likely to be biased

Patients with sulfa allergies, pregnancy, kidney/liver disease, or certain chemotherapy regimens should not receive IV glutathione

Tests should cover full blood count, B12, folate, vitamin D, iron stores, calcium, and other nutrients as clinically indicated

In addition to these mechanisms, HIF-1 also promotes an increase in Interleukin-22 (IL-22), a cytokine that supports cardiomyocyte proliferation and survival

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