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However, peptide drugs suffer from a major drawback of short half-life in the circulation, which limits their bioavailability and their therapeutic potential in chronic neurodegenerative diseases 519

Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men

& Cabandugama, P

Beyond ADCs, they are also used in peptide-drug conjugates, nucleic acid drug delivery systems (such as siRNA and mRNA), nanomedicine carriers, and prodrug designs, providing critical technological support for precision medicine and cancer therapy

Moreover, in vitro uptake experiments in brain slices or cell models with confirmed expression and function of the transporter can be used (124)