PMID 25064324
R 2 is selected from the group consisting of: hydrogen, -CH(R a )OPO(OH)2, -CO-Y, -i-PO(OY) 2 , --PO(OH) 2 , -C(=0)-Y, -CO-U, -C(=0)-(CH 2 )rU, and -CH 2 -V, where R a is hydrogen or CH 3 , where Y is -Z-(CH 2 )q-W-R b , q is 0-4, where Z and W are independently selected from the group consisting of: CH 2 , O, S, R C and R b , where R c is selected from the group consisting of: hydrogen, C1-C4 alkyl, and C 3 -C 6 cycloalkyl, R b is selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C1-C12 alkenyl, C1-C12 substituted alkenyl, C1-C12 alkynyl, C1-C12 substituted alkynyl, C 3 -Cs cycloalkyl, C 3 -Cs substituted cycloalkyl, C 6 -Cio aryl, C 6 -Cio substituted aryl, C 3 -Cs heterocycloalkyl, C 3 -Cs substituted heterocycloalkyl, C4-C10 heteroaryl, and C4-C10 substituted heteroaryl, where r is 0-5, U is selected from aryl, heteroaryl or heterocycloalkyl, where V is -0-C(=0)-Q-(CH 2 )r-R d , where Q is selected from the group consisting of: a bond, O, and N(R C ), where R d is selected from the group consisting of: C6-C10 aryl, C4-C10 heteroaryl, C 3 -Cs heterocycloalkyl, a hexose, a pentose, and - (5-methyl-2-oxo-l,3-dioxol-4-yl)methyl), or alternatively -C(=0)-Y forms an amide bond thru a nitrogen atom on Y in which case Y is a selected from the group consisting of: glycine, sarcosine, ,-diemthyl glycine, alanine, valine, leucine, isoleucine, lysine, ornithine, arigine, serine, and theronine
Boyi Gan and colleagues defined disulfidptosis in 2023 as high SLC7A11 expression and NADPH depletion, resulting in the suppression of cystine/cysteine conversion under conditions of glucose starvation, which leads to disulfide bond accumulation, disulfide stress, and collapse of the cytoskeleton
Bolton WD, Rice DC, Goodyear A, Correa AM, Erasmus JJ, Hofstetter WL, Komaki R, Mehran RJ, Pisters K, Roth JA, Swisher SG , Vaporciyan AA, Walsh GL, Weaver J, Rhines L
A consultation helps determine the right cadence
