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3.9 SNS and RAAS The SNS and the RAAS interact with each other in the form of a positive feedback loop: NE activates ANG II production by stimulating renin secretion, whereas circulating ANG II interacts with the SNS and potentiates NE release from sympathetic nerve terminals (Saxena, 1992

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The two key contributing pathways, genetic damage and lung inflammation , can be further subdivided into discrete, causally linked events, thereby providing a sound mechanistic basis for this assessment

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Despite these challenges, many scientists are increasingly committed to developing and using non-animal methods