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It has a wide spectrum of metabolic effects, including induction of apoptosis via ROS production and cytochrome c release (17), inhibition of NADH oxidation (18), and loss of GSH (19)

ROS generation was detected using a Leica fluorescence microscope (Leica DM6000B) and Leica LAS X software, and the quantitative analysis was performed with ImageJ

AaRSs and translational quality control Faithful translation of the genetic message is paramount for the accurate synthesis of proteins and to prevent the introduction of mutations often associated with loss of function and disease

Porcu A, Gonzalez R, McCarthy MJ

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