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doi: 10.3389/fncel.2013.00193 231 NajemDRennieKRibecco-LutkiewiczMLyDHaukenfrersJLiuQet al

Expression and role of ionotropic glutamate receptors in pancreatic islet cells

Since HLA-DQ2 and HLA-DQ8 heterodimers explain almost 40% of the disease heritability, HLA typing should not be applied in diagnosis, but exclusively to clarify uncertain diagnoses, showing the low negative predictive value for CD diagnosis through HLA genotyping [9, 10]