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Figure 64 is a schematic summarizing exemplary synthetic human antibodies, particularly re-engineered CDR regions, generated by the methods of the invention, as described below

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For example, folic acid has a dual effect on fibroblast proliferation and the alleviation of oxidative stress

The expression and activity of MLCK1 can be increased by a number of cytokines including TNF- [35,36,37] and IL-1 [38], providing evidence for the role of the immune system signalling in affecting paracellular permeability