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From a biomedical perspective, significant research directions include understanding and controlling targeting of NPs to the desired location and the role of the biomolecule corona in driving this, as well as understanding and predicting the impact of the biomolecule corona on drug release rates and reducing off-target effects arising from sub-populations of the NPs being bioprocessed or biodistributed differently to the ideal

doi: 10.1126/science.1250256 132 AndersenJLKornbluthS

Genes Brain Behav 18(2):e12549

doi: 10.1021/acsnano.4c00844 123 SunYBerlethNWuWSchltermannDDeitersenJStuhldreierFet al

This contrasts with the effects of phenylephrine, which produces a pressor response accompanied by a baroreceptor mediated bradycardia, and often an associated decrease in cardiac output