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A double-blind, randomized, placebo-controlled trial in 130 PCOS patients showed the combination of letrozole plus 1,200 mg NAC per day resulted in more follicles greater than 18 mm in diameter (a size associated with greater likelihood of ovulation) after five days than letrozole alone or placebo

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3.5 Molecular mechanisms and regulatory networks of ferroptosis in OC 3.5.1 The role of miRNA, lncRNA, and circRNA in ferroptosis of OC As is shown in Figure 3 , the occurrence of ferroptosis in OC cells is closely related to the expression of multiple RNA molecules, among which miRNA, lncRNA and circRNA play an important role as regulatory factors in the sensitivity and tolerance of ferroptosis

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