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It is becoming increasingly clear that curcumin exhibited both conflicting pro- and anti- oxidants properties as evident from their stimulation of quercetin-induced nuclear DNA damage, lipid peroxidation and protein damage, which was escalated in the presence of Cu or Fe [424]

Spermatogenesis, DNA damage and DNA repair mechanisms in male infertility

Mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems

Multiple injury models, including optic nerve crush, traumatic brain injury, ischemic stroke, and hyperglycemia-induced neurotoxicity, have consistently demonstrated NRN1s ability to reduce neuronal apoptosis (Sharma et al., 2015

2019 Jun;9(3):625-630