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In addition, dendrimerSIN conjugates were demonstrated to selectively target activated microglia/macrophages in a rabbit model of pediatric traumatic brain injury, where they significantly attenuated acute neuroinflammation and oxidative stress compared with the free drug (150)

Alongside these trial failures, other major challenges in developing novel IPF therapies include inadequate animal models, insufficient interventions targeting epithelial repair, and a limited understanding of how cellular senescence contributes to fibrosis (Mora et al., 2017)

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